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May 18, 2016: Invokana Amputation Clinical Trial Finds Drug May Increase Risk

Amputation Invokana

On May 19, 2016, the U.S. Food and Drug Administration issued a Safety Announcement informing the public of a study of the diabetes drug Invokana, the results of which suggest an association between the drug and an increased risk of leg and foot amputations.

Invokana Information

Invokana is a prescription medicine used with diet and exercise to lower blood sugar in adults with type 2 diabetes. This drug belongs to a class of drugs called sodium-glucose cotransporter-2 (SGLT2) inhibitors. SGLT2 inhibitors lower blood sugar by causing the kidneys to remove sugar from the body through the urine. These drugs are marketed to patients as single-ingredient medications, and also in combination with other diabetes medicines such as metformin and linagliptin. Invokana is also known as canagliflozin.

The Amputation Invokana Study

The study of a possible connection between Invokana and an increased risk of amputation titled “Canagliflozin Cardiovascular Assessment Study (CANVAS)” is an ongoing clinical trial. The trial found that amputations occurred about twice as often in patients treated with Invokana compared to patients treated with placebo. The subjects were followed for an average of 4.5 years from this point.

Results of Invokana Amputation Study

The FDA shared the followed results:

Over a year’s time, the risks of amputation for patients in the trial were equivalent to:

  • 7 out of every 1,000 patients treated with 100 mg daily of canagliflozin
  • 5 out of every 1,000 patients treated with 300 mg daily of canagliflozin
  • 3 out of every 1,000 patients treated with placebo



Attorney Eric Weinberg has represented thousands of patients injured by drug adverse events including for example, the products Vioxx, Baycol, Pradaxa, Ortho Evra, and blood clotting products.

If you or a loved one suffered an amputaion after taking Invokana, or developed Invokana ketoacidosis, please contact our firm for a free drug lawsuit evaluation by calling us toll free at 1-877-934-6274. You can also contact a Weinberg Firm personal injury lawyer by submitting our easy-to-use free legal case evaluation form.

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Contact Weinberg Law Firm. You may also call us 24/7 at our toll free number, 1(877) 934-6274.