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Why is Reglan prescribed?

Reglan (metoclopramide) is prescribed for the treatment of gastroesophageal reflux disease, and for the relief of symptoms associated with diabetic gastroparesis including nausea, vomiting, heartburn, persistent fullness after meals, and anorexia.

Reglan belongs to a class of drugs know as dopamine receptor antagonists, and works by increasing stomach emptying (into the upper intestines) and movement of the upper intestines. The drug is available as Reglan Tablets, Reglan Oral Disintegrating Tablets, Metoclopramide Oral Solution, and Reglan Injection. The generic or common name for Reglan is metoclopromide.

What are the complications associated with taking Reglan?

On February 26, 2009, the FDA advised the manufacturers of Reglan and other metoclopramide-containing drugs to include a “Boxed Warning” in the product’s labeling alerting doctors and patients of the risk for developing tardive dyskinesia in patients taking Reglan. The risk for developing metoclopramide-associated tardive dyskinesia increases with long-term or high-dose Reglan use. A “Boxed Warning” is the strongest warning the FDA can require a prescription drug to carry in its labeling.

Tardive dyskinesia is characterized by involuntary, repetitive movements of the extremities or face (including grimacing, tongue protrusion, lip smacking, puckering and pursing of the lips, and rapid eye blinking) or impaired movements of the fingers. The symptoms are rarely reversible, and there is no known treatment. However, in some patients symptoms may lessen or resolve after metoclopramide therapy is discontinued.

According to the FDA, the development of tardive dyskinesia is directly related to the length of time and the number of doses of Reglan taken. The elderly (particularly older women) and people who have taken Reglan for a long time are at greatest risk for developing tardive dyskinesia.

What should I do if I have experienced tardive dyskinesia –like symptoms?

Patients should immediately contact their doctor or health care professional if they experience tardive dyskinesia-like symptoms. Consumers are also encouraged to report suspected Reglan side effects or product quality problems to the FDA’s MedWatch Adverse Event Reporting program at, or by phone 800-FDA-1088.

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The Weinberg Law Firm has represented thousands of individuals injured by dangerous, defective, or mislabeled medications, including for example, Vioxx, Pradaxa, Baycol, contaminated Blood Clotting Factors, and Ortho Evra. We have obtained over $800 million on behalf of the firm’s personal injury clients. For a free drug lawsuit case evaluation, please contact us at 1-877-934-6274.

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